Phase I Study of Intravenous Triapine (IND # 68338) in Combination With Pelvic Radiation Therapy With or Without Weekly Intravenous Cisplatin Chemotherapy for Locally Advanced Cervical, Vaginal, or Pelvic Gynecologic Malignancies

NCT00335998 · clinicaltrials.gov ↗

PHASE1

Phase

COMPLETED

Status

24

Enrollment

NIH

Sponsor class

Conditions

Recurrent Cervical Cancer
Recurrent Ovarian Epithelial Cancer
Recurrent Vaginal Cancer
Recurrent Vulvar Cancer
Stage III Vaginal Cancer
Stage IIIA Cervical Cancer
Stage IIIA Ovarian Epithelial Cancer
Stage IIIA Vulvar Cancer
Stage IIIB Cervical Cancer
Stage IIIB Ovarian Epithelial Cancer
Stage IIIB Vulvar Cancer
Stage IIIC Ovarian Epithelial Cancer
Stage IIIC Vulvar Cancer
Stage IV Ovarian Epithelial Cancer
Stage IVA Cervical Cancer
Stage IVA Vaginal Cancer
Stage IVB Cervical Cancer
Stage IVB Vaginal Cancer

Interventions

DRUG: triapine
OTHER: laboratory biomarker analysis
RADIATION: external beam radiation therapy
RADIATION: brachytherapy
DRUG: cisplatin
OTHER: pharmacological study

Sponsor

National Cancer Institute (NCI)