Decitabine in Treating Patients With Previously Untreated Acute Myeloid Leukemia

Conditions

• Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities
• Adult Acute Myeloid Leukemia With Del(5q)
• Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)
• Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)
• Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)
• Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)
• Secondary Acute Myeloid Leukemia
• Untreated Adult Acute Myeloid Leukemia

Interventions

• DRUG: decitabine
• OTHER: laboratory biomarker analysis
• OTHER: pharmacological study
• OTHER: high performance liquid chromatography
• GENETIC: microarray analysis
• GENETIC: RNA analysis
• OTHER: mass spectrometry
• GENETIC: DNA methylation analysis
• OTHER: matrix-assisted laser desorption/ionization time of flight mass spectrometry

Sponsor

National Cancer Institute (NCI)