Combination Chemotherapy and Radiation Therapy With or Without Lapatinib in Treating Patients With Locally Advanced Cancer of the Larynx or Hypopharynx

Conditions

• Head and Neck Cancer

Interventions

• DRUG: carboplatin
• DRUG: cisplatin
• DRUG: docetaxel
• DRUG: fluorouracil
• DRUG: lapatinib ditosylate
• GENETIC: cytogenetic analysis
• GENETIC: fluorescence in situ hybridization
• GENETIC: in situ hybridization
• GENETIC: polymerase chain reaction
• GENETIC: reverse transcriptase-polymerase chain reaction
• OTHER: immunohistochemistry staining method
• OTHER: laboratory biomarker analysis
• PROCEDURE: conventional surgery
• PROCEDURE: neoadjuvant therapy
• RADIATION: fludeoxyglucose F 18
• RADIATION: radiation therapy

Sponsor

European Organisation for Research and Treatment of Cancer - EORTC