Zoledronic Acid and Combination Chemotherapy in Treating Patients With Newly Diagnosed Metastatic Osteosarcoma

NCT00742924 · clinicaltrials.gov ↗

PHASE1

Phase

COMPLETED

Status

24

Enrollment

NETWORK

Sponsor class

Conditions

Sarcoma

Interventions

DRUG: cisplatin
DRUG: dexrazoxane hydrochloride
DRUG: doxorubicin hydrochloride
DRUG: etoposide
DRUG: ifosfamide
DRUG: leucovorin calcium
DRUG: methotrexate
DRUG: zoledronic acid
PROCEDURE: adjuvant therapy
PROCEDURE: neoadjuvant therapy
PROCEDURE: therapeutic conventional surgery
BIOLOGICAL: filgrastim
DRUG: Mesna

Sponsor

Children's Oncology Group

Collaborators

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