Donor Peripheral Blood Stem Cell Transplant and Pretargeted Radioimmunotherapy in Treating Patients With High-Risk Advanced Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or Myelodysplastic Syndrome
Conditions
- Chronic Myelomonocytic Leukemia
- Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable
- Previously Treated Myelodysplastic Syndrome
- Recurrent Adult Acute Lymphoblastic Leukemia
- Recurrent Adult Acute Myeloid Leukemia
- Refractory Anemia With Excess Blasts
- Refractory Cytopenia With Multilineage Dysplasia
- Refractory Cytopenia With Multilineage Dysplasia and Ringed Sideroblasts
- Secondary Acute Myeloid Leukemia
Interventions
- BIOLOGICAL: Pretargeted Radioimmunotherapy
- DRUG: Cyclosporine
- DRUG: Mycophenolate Mofetil
- RADIATION: Total-Body Irradiation
- PROCEDURE: Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation
- PROCEDURE: Peripheral Blood Stem Cell Transplantation
- DRUG: Fludarabine Phosphate
- OTHER: Pharmacological Study
- OTHER: Laboratory Biomarker Analysis
Sponsor
Fred Hutchinson Cancer Center
Collaborators