T-Regulatory Cell and CD3 Depleted Double Umbilical Cord Blood Transplantation in Hematologic Malignancies

Stopped Replaced by a new study

Conditions

• Hematologic Malignancy
• Acute Myeloid Leukemia
• Acute Lymphocytic Leukemia
• Chronic Myelogenous Leukemia in Blast Crisis
• Anemia, Refractory, With Excess of Blasts
• Chronic Myeloproliferative Disease
• Chronic Lymphocytic Leukemia
• Small Lymphocytic Lymphoma
• Marginal Zone B-cell Lymphoma
• Follicular Lymphoma
• Lymphoplasmacytic Lymphoma
• Mantle-Cell Lymphoma
• Prolymphocytic Lymphoma
• Large Cell Non-Hodgkin's Lymphoma
• Lymphoblastic Lymphoma
• Burkitt's Lymphoma
• High Grade Non-Hodgkin's Lymphoma

Interventions

• BIOLOGICAL: Treg cells
• BIOLOGICAL: CD3+ Teff cells
• DRUG: Fludarabine
• DRUG: Cyclophosphamide
• RADIATION: Total body irradiation
• BIOLOGICAL: Umbilical cord blood transplantation

Sponsor

Masonic Cancer Center, University of Minnesota