RO4929097 and Whole-Brain Radiation Therapy or Stereotactic Radiosurgery in Treating Patients With Brain Metastases From Breast Cancer

NCT01217411 · clinicaltrials.gov ↗

PHASE1,PHASE2

Phase

TERMINATED

Status

5

Enrollment

NIH

Sponsor class

Stopped Other - Protocol moved to Administratively Complete

Conditions

Adult Solid Neoplasm
Extensive Stage Lung Small Cell Carcinoma
HER2/Neu Negative
HER2/Neu Positive
Male Breast Carcinoma
Metastatic Malignant Neoplasm in the Brain
Recurrent Breast Carcinoma
Recurrent Lung Non-Small Cell Carcinoma
Recurrent Lung Small Cell Carcinoma
Recurrent Melanoma
Stage IV Breast Cancer AJCC v6 and v7
Stage IV Cutaneous Melanoma AJCC v6 and v7
Stage IV Lung Non-Small Cell Cancer AJCC v7

Interventions

PROCEDURE: Cognitive Assessment
DRUG: Gamma-Secretase Inhibitor RO4929097
OTHER: Laboratory Biomarker Analysis
RADIATION: Stereotactic Radiosurgery
RADIATION: Whole-Brain Radiotherapy

Sponsor

National Cancer Institute (NCI)