Decitabine and Total-Body Irradiation Followed By Donor Bone Marrow Transplant and Cyclophosphamide in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia
Conditions
- Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome
- Adult Acute Myeloid Leukemia in Remission
- Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities
- Adult Acute Myeloid Leukemia With Del(5q)
- Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)
- Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)
- Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)
- Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)
- de Novo Myelodysplastic Syndromes
- Previously Treated Myelodysplastic Syndromes
- Recurrent Adult Acute Myeloid Leukemia
- Secondary Acute Myeloid Leukemia
Interventions
- DRUG: decitabine
- DRUG: fludarabine phosphate
- DRUG: busulfan
- DRUG: cyclophosphamide
- DRUG: tacrolimus
- DRUG: mycophenolate mofetil
- BIOLOGICAL: filgrastim
- RADIATION: total-body irradiation
- PROCEDURE: allogeneic bone marrow transplantation
- OTHER: laboratory biomarker analysis
Sponsor
University of Wisconsin, Madison
Collaborators