Brain Muscle Axis During Treatment of Hepatic Encephalopathy With L-ornithine L-aspartate

Conditions

• Hepatic Encephalopathy
• Minimal Hepatic Encephalopathy
• Cirrhosis

Interventions

• PROCEDURE: Vastus Muscle Biopsy
• DRUG: LOLA or placebo
• OTHER: Cognitive assessment (PHES)
• OTHER: Cognitive Assessement (Cogstate)
• OTHER: blood and urine sampling
• OTHER: Nutritional assessment
• OTHER: MRI brain and spectroscopy
• OTHER: MRI leg cross section
• OTHER: Functional MRI (working memory and attention tasks)

Sponsor

Imperial College London