Combined T Cell Depleted Haploidentical Peripheral Blood Stem Cell and Unrelated Umbilical Cord Blood Transplantation in Patients With Hematologic Malignancies Using a Total Lymphoid Irradiation Based Preparative Regimen

NCT02199041 · clinicaltrials.gov ↗

PHASE2

Phase

TERMINATED

Status

24

Enrollment

OTHER

Sponsor class

Stopped The study was halted early due to slow accrual.

Conditions

Hematological Malignancies

Interventions

DRUG: Cyclophosphamide
DRUG: Thiotepa
DRUG: Fludarabine
DRUG: Melphalan
DRUG: Mesna
BIOLOGICAL: G-CSF
DRUG: Mycophenolate mofetil
DRUG: Tacrolimus
DRUG: Methylprednisolone
RADIATION: Total lymphoid irradiation
BIOLOGICAL: Lymphocyte infusions
DEVICE: CliniMACS

Sponsor

St. Jude Children's Research Hospital