Selective Depletion of CD45RA+ T Cells From Allogeneic Peripheral Blood Stem Cell Grafts From HLA-Matched Related and Unrelated Donors in Preventing GVHD

Conditions

• Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive
• Acute Biphenotypic Leukemia
• Acute Leukemia of Ambiguous Lineage
• Acute Undifferentiated Leukemia
• Allogeneic Hematopoietic Stem Cell Transplant Recipient
• Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive
• Blastic Plasmacytoid Dendritic Cell Neoplasm
• Childhood Acute Lymphoblastic Leukemia in Remission
• Childhood Acute Myeloid Leukemia in Remission
• Donor
• Lymphoblastic Lymphoma
• Myelodysplastic Syndrome With Excess Blasts
• Myelodysplastic Syndrome With Excess Blasts-1
• Myelodysplastic Syndrome With Excess Blasts-2
• Recurrent Acute Lymphoblastic Leukemia
• Recurrent Acute Myeloid Leukemia
• Recurrent Childhood Acute Lymphoblastic Leukemia
• Recurrent Childhood Acute Myeloid Leukemia
• Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive
• Refractory Acute Lymphoblastic Leukemia
• Refractory Acute Myeloid Leukemia
• Acute Lymphoblastic Leukemia in Remission
• Acute Myeloid Leukemia in Remission

Interventions

• PROCEDURE: Allogeneic Hematopoietic Stem Cell Transplantation
• DRUG: Cyclophosphamide
• DRUG: Fludarabine Phosphate
• OTHER: Laboratory Biomarker Analysis
• DRUG: Methotrexate
• DRUG: Mycophenolate Mofetil
• PROCEDURE: Peripheral Blood Stem Cell Transplantation
• PROCEDURE: Peripheral Blood Stem Cell Transplantation
• DRUG: Tacrolimus
• DRUG: Thiotepa
• RADIATION: Total-Body Irradiation

Sponsor

Fred Hutchinson Cancer Center

Collaborators

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