Oral Steroids for Regorafenib-induced Fatigue/Malaise in Unresectable mCRC (KSCC1402/HGCSG1402)

Conditions

• Rectal Cancer

Interventions

• OTHER: General condition
• OTHER: Blood pressure
• OTHER: Patient Reported Outcome
• OTHER: Clinical findings
• OTHER: Hematology/blood chemistry
• OTHER: Coagulation and fibrinolysis system
• OTHER: Urinalysis
• OTHER: Medication check
• OTHER: Adverse event
• OTHER: Thyroid function test
• OTHER: Contrast-enhanced torso CT
• OTHER: Brain MRI
• DRUG: Dexamethasone
• DRUG: Regorafenib
• DRUG: Placebo
• DRUG: Proton pump inhibitor

Sponsor

Clinical Research Support Center Kyush