Testing the Addition of a New Anti-Cancer Drug, Triapine, to the Usual Chemotherapy Treatment (Cisplatin) During Radiation Therapy for Advanced-stage Cervical and Vaginal Cancers

Conditions

• Advanced Vaginal Adenocarcinoma
• Advanced Vaginal Adenosquamous Carcinoma
• Advanced Vaginal Squamous Cell Carcinoma
• Cervical Adenocarcinoma
• Cervical Adenosquamous Carcinoma
• Cervical Squamous Cell Carcinoma
• Stage IB2 Cervical Cancer AJCC v6 and v7
• Stage II Cervical Cancer AJCC v7
• Stage II Vaginal Cancer AJCC v6 and v7
• Stage IIA Cervical Cancer AJCC v7
• Stage IIB Cervical Cancer AJCC v6 and v7
• Stage III Vaginal Cancer AJCC v6 and v7
• Stage IIIB Cervical Cancer AJCC v6 and v7
• Stage IV Vaginal Cancer AJCC v6 and v7
• Stage IVA Cervical Cancer AJCC v6 and v7
• Stage IVA Vaginal Cancer AJCC v6 and v7
• Unresectable Vaginal Carcinoma
• Vaginal Adenocarcinoma
• Vaginal Adenosquamous Carcinoma
• Vaginal Carcinoma
• Vaginal Squamous Cell Carcinoma, Not Otherwise Specified

Interventions

• RADIATION: Brachytherapy
• DRUG: Cisplatin
• RADIATION: External Beam Radiation Therapy
• RADIATION: Intensity-Modulated Radiation Therapy
• OTHER: Laboratory Biomarker Analysis
• RADIATION: Radiation Therapy
• DRUG: Triapine

Sponsor

National Cancer Institute (NCI)

Collaborators

• [object Object]