Phase II Study of Intraventricular Methotrexate in Children With Recurrent or Progressive Malignant Brain Tumors

NCT02684071 · clinicaltrials.gov ↗

PHASE2

Phase

TERMINATED

Status

3

Enrollment

OTHER

Sponsor class

Stopped Lack of additional funding; patients (3) no longer receiving intervention.

Conditions

Recurrent Childhood Medulloblastoma
Recurrent Childhood Ependymoma
Childhood Atypical Teratoid/Rhabdoid Tumor
Embryonal Tumor With Abundant Neuropil and True Rosettes
Metastatic Malignant Neoplasm to the Leptomeninges

Interventions

DRUG: Intra thecal methotrexate
DRUG: topotecan
DRUG: cyclophosphamide

Sponsor

Nicklaus Children's Hospital f/k/a Miami Children's Hospital