Molecular Investigation of Genetic Factors in CArDiovascular Diseases Using an BIOresource of Healthy Volunteers

Stopped The delay due to suspending the study due to covid, subsequent problems in synthesis, supply and yield of BQ123, prevented completion of the study as planned.

Conditions

• Cardiovascular Diseases

Interventions

• OTHER: Eligibility and lifestyle restrictions check.
• OTHER: Medical history, demographic and lifestyle factors
• OTHER: Anthropometric measurements: height, weight, and body fat
• OTHER: Blood pressure and heart rate
• OTHER: Forearm blood flow: Visit 1 (EDNRA)
• OTHER: Forearm blood flow: Visit 2 (EDNRA)
• OTHER: Blood biochemistry (PNPLA3)
• OTHER: Blood EPCR function (PROCR)
• OTHER: Blood platelet coagulation and function (PROCR)
• OTHER: Blood endothelial permeability (PROCR)
• OTHER: Blood leukocyte-endothelium adhesion (PROCR)
• OTHER: Baseline Venepuncture (PNPLA3, Visit 1)
• OTHER: Deuterium water - Loading dose 1 (PNPLA3, Visit 1)
• OTHER: Deuterium water - Loading dose 2 (PNPLA3, Visit 1)
• OTHER: Energy-balanced dinner (PNPLA3, Visit 1)
• OTHER: Fasting venepuncture (PNPLA3, Visit 2)
• OTHER: Deuterium water - Maintenance dose (PNPLA3, Visit 2)
• OTHER: Consumption of high carbohydrate meal (PNPLA3, Visit 2)
• OTHER: Postprandial Venepuncture (PNPLA3, Visit 2)
• OTHER: Venepuncture (PROCR)

Sponsor

Cambridge University Hospitals NHS Foundation Trust

Collaborators

• [object Object]