INvestigating the Lowest Threshold of Vascular bENefits From LDL Lowering With a PCSK9 InhibiTor in healthY Volunteers

Conditions

• Atherosclerosis
• Cardiovascular Diseases

Interventions

• OTHER: Written Informed Consent
• OTHER: Inclusion/Exclusion check
• OTHER: Full Clinical Chemistry and Haematology Bloods
• OTHER: Serum sample for systemic markers and lipid sub-fractions
• OTHER: Pregnancy Test
• OTHER: 12 Lead ECG
• OTHER: Blood Pressure and Heart Rate
• OTHER: Arterial Stiffness
• OTHER: Central Haemodynamics
• OTHER: Carotid Intima Media Thickness
• OTHER: Forearm blood flow studies
• OTHER: Concomitant medication check
• OTHER: Medication compliance check (Pill count)
• OTHER: Physical examination
• OTHER: Medical history
• OTHER: AE/SAE review & reporting
• DRUG: Dosing

Sponsor

Cambridge University Hospitals NHS Foundation Trust

Collaborators

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