Testing AZD1775 inC Combination With Radiotherapy and Chemotherapy in Cervical, Upper Vaginal and Uterine Cancers

NCT03345784 · clinicaltrials.gov ↗

PHASE1

Phase

TERMINATED

Status

10

Enrollment

NIH

Sponsor class

Stopped Inadequate accrual rate

Conditions

Cervical Carcinoma
Endometrioid Adenocarcinoma
Malignant Female Reproductive System Neoplasm
Recurrent Cervical Carcinoma
Stage I Uterine Corpus Cancer AJCC v7
Stage I Vaginal Cancer AJCC v6 and v7
Stage IA Uterine Corpus Cancer AJCC v7
Stage IB Cervical Cancer AJCC v6 and v7
Stage IB Uterine Corpus Cancer AJCC v7
Stage IB2 Cervical Cancer AJCC v6 and v7
Stage II Cervical Cancer AJCC v7
Stage II Uterine Corpus Cancer AJCC v7
Stage II Vaginal Cancer AJCC v6 and v7
Stage IIA Cervical Cancer AJCC v7
Stage IIB Cervical Cancer AJCC v6 and v7
Stage III Cervical Cancer AJCC v6 and v7
Stage III Uterine Corpus Cancer AJCC v7
Stage III Vaginal Cancer AJCC v6 and v7
Stage IIIA Cervical Cancer AJCC v6 and v7
Stage IIIA Uterine Corpus Cancer AJCC v7
Stage IIIB Cervical Cancer AJCC v6 and v7
Stage IIIB Uterine Corpus Cancer AJCC v7
Stage IIIC Uterine Corpus Cancer AJCC v7
Vaginal Carcinoma

Interventions

DRUG: Adavosertib
DRUG: Cisplatin
RADIATION: External Beam Radiation Therapy

Sponsor

National Cancer Institute (NCI)