Role of Extracellular Matrix in the Development of Airway Remodeling in Asthma

NCT03388359 · clinicaltrials.gov ↗

NA

Phase

UNKNOWN

Status

60

Enrollment

OTHER

Sponsor class

Conditions

Allergic Asthma
Airway Remodelling
Extracellular Matrix Alteration

Interventions

PROCEDURE: Bronchial challenge with allergen
OTHER: Co-culture formation
OTHER: Inhibition of Wnt and Smad signaling pathways
OTHER: Extracellular matrix turnover and deposition assessment
BIOLOGICAL: Dermatophagoides pteronyssinus allergen
DEVICE: Dosimeter ProvoX (Ganshorn)
BIOLOGICAL: Eosinophils
BIOLOGICAL: Airway smooth muscle cells
BIOLOGICAL: Fibroblasts

Sponsor

Lithuanian University of Health Sciences

Collaborators

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