Brain Stem Gliomas Treated With Adoptive Cellular Therapy During Focal Radiotherapy Recovery Alone or With Dose-intensified Temozolomide (Phase I)

NCT03396575 · clinicaltrials.gov ↗

PHASE1

Phase

TERMINATED

Status

11

Enrollment

OTHER

Sponsor class

Stopped Not feasible to accrue due to competing studies

Conditions

Diffuse Intrinsic Pontine Glioma (DIPG)
Brain Stem Glioma

Interventions

BIOLOGICAL: TTRNA-DC vaccines with GM-CSF
BIOLOGICAL: TTRNA-xALT
DRUG: Cyclophosphamide + Fludarabine Lymphodepletive Conditioning
DRUG: Dose-Intensified TMZ
DRUG: Td vaccine
BIOLOGICAL: Autologous Hematopoietic Stem Cells (HSC)

Sponsor

University of Florida

Collaborators

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