Precision Diagnosis Directing HDACi Chidamide Target Therapy for Adult T-LBL/ALL

NCT03564704 · clinicaltrials.gov ↗

PHASE2,PHASE3

Phase

UNKNOWN

Status

80

Enrollment

OTHER

Sponsor class

Conditions

Leukemia
Leukemia, Acute
Adult Lymphoblastic Lymphoma
Leukemia, Lymphoblastic
Leukemia, T Cell
Adult Acute Lymphoblastic Leukemia
Lymphoblastic Lymphoma
Lymphoblastic Leukemia

Interventions

DRUG: Dexamethasone
DRUG: vincristine
DRUG: Cyclophosphamide
DRUG: Idarubicin
DRUG: Pegaspargase
DRUG: Adriamycin
DRUG: Methotrexate
DRUG: 6-mercaptopurine.
DRUG: Etoposide
DRUG: Cytarabine
PROCEDURE: Bone marrow aspiration
PROCEDURE: Intrathecal injection
RADIATION: Radiation therapy
GENETIC: NGS
PROCEDURE: allogeneic hematopoietic stem cell transplantation
DIAGNOSTIC_TEST: Flow-MRD
DIAGNOSTIC_TEST: FISH
DIAGNOSTIC_TEST: Flow immunophenotyping
DIAGNOSTIC_TEST: Karyotyping
DRUG: Chidamide

Sponsor

Nanfang Hospital, Southern Medical University