Alpha-Defensin and Synovial Proteins to Improve Detection of Pediatric Septic Arthritis

Conditions

• Joint Infection
• Infection of Hip Joint (Disorder)
• Infection of Shoulder Joint
• Septic Arthritis

Interventions

• DIAGNOSTIC_TEST: Synovial Alpha-defensin assay
• DIAGNOSTIC_TEST: Synovial Neutrophil elastase assay
• DIAGNOSTIC_TEST: Synovial lactate assay
• DIAGNOSTIC_TEST: Synovial C-reactive Protein (CRP)
• DIAGNOSTIC_TEST: Synovial Staphylococcus spp antigen panel
• DIAGNOSTIC_TEST: Synovial Candida spp antigen panel
• DIAGNOSTIC_TEST: Synovial Enterococcus faecalis assay
• DIAGNOSTIC_TEST: Synovial bacterial culture by BacT/Alert
• DIAGNOSTIC_TEST: Synovial Cell count + differential (CBC)
• DIAGNOSTIC_TEST: Synovial Gram Stain
• DIAGNOSTIC_TEST: Synovial Leukocyte Esterase Test Strips
• DIAGNOSTIC_TEST: Synovial PCR for Kingella kingae
• DIAGNOSTIC_TEST: Serum Cell count + differential (CBC)
• DIAGNOSTIC_TEST: Serum erythrocyte sedimentation rate (ESR)
• DIAGNOSTIC_TEST: Serum C-reactive Protein (CRP)
• DIAGNOSTIC_TEST: Serum D-dimer
• DIAGNOSTIC_TEST: Serum Procalcitonin
• DIAGNOSTIC_TEST: Blood Cultures
• DIAGNOSTIC_TEST: Optional blood testing per standard of care (ASO, anti-strep, ANA, anti-DS-DNA, HLA-B27, RF, Lyme and other inflammatory/ rheumatologic markers )

Sponsor

Hospital for Special Surgery, New York

Collaborators

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