An Exploratory Study in Healthy Volunteers to Investigate the Cross-talk Between Local Drug Concentrations in the Skin and Systemic Concentrations During Topical Bioequivalence Studies Using Dermal Sampling Techniques

Conditions

• Healthy
• Dermal Pharmacokinetic Measurement

Interventions

• PROCEDURE: Intravenous infusion of lidocaine
• DRUG: Lidocaine 2.5% and Prilocaine 2.5% cream", USP (2.5% lidocaine, 2.5% prilocaine, Actavis Pharma incorporated, USA)
• DRUG: Lidocorit 2%-Ampullen" (Gebro Pharma Gesellschaft mit beschränkter Haftung, Austria)
• DEVICE: Dermal open flow microperfusion
• DEVICE: Dermal Microdialysis
• PROCEDURE: Blood sampling in dermal sampling visit
• PROCEDURE: Blood sampling in clearance visit

Sponsor

Joanneum Research Forschungsgesellschaft mbH