TCRαβ-depleted Progenitor Cell Graft With Additional Memory T-cell DLI, Plus Selected Use of Blinatumomab, in Naive T-cell Depleted Haploidentical Donor Hematopoietc Cell Transplantation for Hematologic Malignancies

NCT03849651 · clinicaltrials.gov ↗

PHASE2

Phase

ACTIVE_NOT_RECRUITING

Status

69

Enrollment

OTHER

Sponsor class

Conditions

Acute Lymphoblastic Leukemia (ALL)
Acute Myeloid Leukemia (AML)
Myelodysplastic Syndromes (MDS)
NK-Cell Leukemia
Hodgkin Lymphoma
Non Hodgkin Lymphoma (NHL)
Juvenile Myelomonocytic Leukemia (JMML)
Chronic Myeloid Leukemia (CML)

Interventions

DRUG: Cyclophosphamide
BIOLOGICAL: Fludarabine
DRUG: Thiotepa
DRUG: Melphalan
BIOLOGICAL: G-csf
DRUG: Mesna
DEVICE: CliniMACS
BIOLOGICAL: ATG (rabbit)
DRUG: Blinatumomab
BIOLOGICAL: TCRα/β+
BIOLOGICAL: CD19+
BIOLOGICAL: CD45RA-depleted DLI

Sponsor

St. Jude Children's Research Hospital