Modified Immune Cells (Autologous Dendritic Cells) and a Vaccine (Prevnar) Combined With Immune Checkpoint Inhibition After High-Dose External Beam Radiation Therapy in Treating Patients With Unresectable Liver Cancer
Conditions
- Stage III Hepatocellular Carcinoma AJCC v8
- Stage III Intrahepatic Cholangiocarcinoma AJCC v8
- Stage IV Hepatocellular Carcinoma AJCC v8
- Stage IV Intrahepatic Cholangiocarcinoma AJCC v8
- Unresectable Hepatocellular Carcinoma
- Unresectable Intrahepatic Cholangiocarcinoma
Interventions
- BIOLOGICAL: Atezolizumab
- BIOLOGICAL: Bevacizumab
- RADIATION: External Beam Radiation Therapy
- PROCEDURE: Pheresis
- BIOLOGICAL: Pneumococcal 13-valent Conjugate Vaccine
- BIOLOGICAL: Therapeutic Autologous Dendritic Cells
- BIOLOGICAL: Durvalumab
- PROCEDURE: Esophagogastroduodenoscopy
- PROCEDURE: Computed Tomography
- PROCEDURE: Positron Emission Tomography
- PROCEDURE: Magnetic Resonance Imaging
- PROCEDURE: Biopsy Procedure
- PROCEDURE: Biospecimen Collection
Sponsor
Mayo Clinic
Collaborators