Sanaria PfSPZ Challenge With Pyrimethamine or Chloroquine Chemoprophylaxis Vaccination (PfSPZ-CVac Approach): A Randomized Double Blind Placebo Controlled Phase I/II Trial to Determine Safety and Protective Efficacy Against Natural Plasmodium Falcipa...

NCT03952650 · clinicaltrials.gov ↗

PHASE1,PHASE2

Phase

COMPLETED

Status

252

Enrollment

NIH

Sponsor class

Conditions

Malaria

Interventions

DRUG: Chloroquine Phosphate
BIOLOGICAL: PfSPZ Challenge
DRUG: Pyrimethamine
DRUG: Coartem
DRUG: ibuprofen

Sponsor

National Institute of Allergy and Infectious Diseases (NIAID)