Graft Versus Host Disease-Reduction Strategies for Donor Blood Stem Cell Transplant Patients With Acute Leukemia or Myelodysplastic Syndrome (MDS)

NCT03970096 · clinicaltrials.gov ↗

PHASE2

Phase

RECRUITING

Status

120

Enrollment

OTHER

Sponsor class

Conditions

Acute Leukemia
Acute Lymphoblastic Leukemia
Acute Myeloid Leukemia
Myelodysplastic Syndrome
Myeloproliferative Neoplasm

Interventions

RADIATION: Total-Body Irradiation
DRUG: Thiotepa
DRUG: Fludarabine
DRUG: Tacrolimus
BIOLOGICAL: Allogeneic CD34+-enriched and CD45RA-depleted PBSCs
DRUG: Methotrexate
DRUG: Cyclophosphamide
BIOLOGICAL: Peripheral Blood Stem Cell
DRUG: Cyclosporine
DRUG: Sirolimus
DRUG: Busulfan
PROCEDURE: Bone Marrow Aspiration and Biopsy
PROCEDURE: Echocardiography
PROCEDURE: Multigated Acquisition Scan
PROCEDURE: Biospecimen Collection

Sponsor

Fred Hutchinson Cancer Center

Collaborators

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