Impact of Bariatric Surgery on Pharmacokinetic Study of Simvastatin and Carvedilol

NCT04049786 · clinicaltrials.gov ↗

PHASE4

Phase

UNKNOWN

Status

120

Enrollment

OTHER

Sponsor class

Conditions

Obesity
Bariatric Surgery
Roux-en Y Gastric Bypass

Interventions

PROCEDURE: Digestive biopsy
DRUG: Carvedilol 25mg
PROCEDURE: Serial blood sampling for PK analysis
DRUG: Metoprolol 100 mg for CYP2D6 phenotyping
DRUG: Simvastatin 40mg
DRUG: Midazolam 2 mg for CYP3A4 phenotyping
OTHER: Genotyping

Sponsor

Natalia Valadares de Moraes

Collaborators

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