Maximising Time With a Normal Blood Glucose to Restore the Glucagon Response in Type 1 Diabetes

NCT04614168 · clinicaltrials.gov ↗

NA

Phase

COMPLETED

Status

24

Enrollment

OTHER

Sponsor class

Conditions

Type 1 Diabetes
Type 1 Diabetes Mellitus With Hypoglycemia
Hypoglycemia
Hypoglycemia Unawareness
Glucagon Deficiency
Insulin Hypoglycemia

Interventions

PROCEDURE: Stepped hyperinsulinaemic-hypoglycaemic clamp study
DEVICE: Insulin pump
DEVICE: Continuous glucose monitor
OTHER: Low carbohydrate diet
DEVICE: Blinded continuous glucose monitor
PROCEDURE: Stable isotope studies- D2 Glucose and D5 Glycerol

Sponsor

University of Edinburgh

Collaborators

NHS Lothian
The Leona M. and Harry B. Helmsley Charitable Trust
Tandem Diabetes Care, Inc.
DexCom, Inc.