Platform of Randomized Adaptive Clinical Trials in Critical Illness

Conditions

• Respiratory Insufficiency
• Extracorporeal Membrane Oxygenation Complication
• Mechanical Ventilation Pressure High

Interventions

• OTHER: Ultra-Protective Ventilation Facilitated by Extracorporeal Support
• OTHER: Lung-Protective Ventilation (LPV)
• OTHER: Driving Pressure-Limited Ventilation (DPL)
• OTHER: Lung- and Diaphragm-Protective Ventilation and Sedation (LDPVS)
• DRUG: Early Cohort corticosteroid dose
• DRUG: Extended Cohort corticosteroid dose
• DRUG: Usual care without routine corticosteroids
• DRUG: Usual care without extending corticosteroids
• DRUG: Usual care with fludrocortisone
• DRUG: Usual care without fludrocortisone
• DRUG: Drug 4 mL:
• DRUG: Drug 40 mg:
• OTHER: PEEP-20
• OTHER: PEEP-AOP
• OTHER: PEEP-10
• OTHER: VV ECMO-facilitated strategy of earlier awakening, extubation and rehabilitation
• OTHER: Electrical impedance tomography (EIT)
• OTHER: no treatment / intervention arm is involved
• OTHER: Usual care
• OTHER: Early Routine IMT

Sponsor

University Health Network, Toronto