Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

NCT05564377 · clinicaltrials.gov ↗

PHASE2

Phase

RECRUITING

Status

2900

Enrollment

NIH

Sponsor class

Conditions

Advanced Malignant Solid Neoplasm
Anatomic Stage III Breast Cancer AJCC v8
Anatomic Stage IV Breast Cancer AJCC v8
Locally Advanced Malignant Solid Neoplasm
Malignant Female Reproductive System Neoplasm
Metastatic HER2-Negative Breast Carcinoma
Metastatic Malignant Solid Neoplasm
Recurrent Endometrial Carcinoma
Recurrent Fallopian Tube Carcinoma
Recurrent Malignant Female Reproductive System Neoplasm
Recurrent Malignant Solid Neoplasm
Recurrent Ovarian Carcinoma
Recurrent Primary Peritoneal Carcinoma
Unresectable HER2-Negative Breast Carcinoma
Unresectable Malignant Solid Neoplasm

Interventions

DRUG: Alpelisib
DRUG: Binimetinib
PROCEDURE: Biopsy Procedure
PROCEDURE: Biospecimen Collection
PROCEDURE: Bone Marrow Aspiration
PROCEDURE: Bone Marrow Biopsy
PROCEDURE: Bone Scan
PROCEDURE: Computed Tomography
PROCEDURE: Echocardiography Test
DRUG: Fluorouracil
DRUG: Fulvestrant
DRUG: Ipatasertib
DRUG: Leucovorin
PROCEDURE: Magnetic Resonance Imaging
PROCEDURE: Multigated Acquisition Scan
PROCEDURE: Mutation Carrier Screening
DRUG: Neratinib Maleate
DRUG: Nilotinib Hydrochloride Monohydrate
DRUG: Olaparib
DRUG: Oxaliplatin

Sponsor

National Cancer Institute (NCI)