Intracerebroventricular Administration of CD19-CAR T Cells (CD19CAR-CD28-CD3zeta-EGFRt-expressing Tn/Mem T-lymphocytes) for the Treatment of Central Nervous System Lymphoma

NCT05625594 · clinicaltrials.gov ↗

PHASE1

Phase

RECRUITING

Status

20

Enrollment

OTHER

Sponsor class

Conditions

Central Nervous System Lymphoma

Interventions

PROCEDURE: Aspiration
PROCEDURE: Biospecimen Collection
PROCEDURE: Catheterization
BIOLOGICAL: CD19CAR-CD28-CD3zeta-EGFRt-expressing Tn/mem T-lymphocytes
PROCEDURE: Computed Tomography
DRUG: Cyclophosphamide
DRUG: Fludarabine
PROCEDURE: Leukapheresis
PROCEDURE: Lumbar Puncture
PROCEDURE: Magnetic Resonance Imaging
PROCEDURE: Positron Emission Tomography

Sponsor

City of Hope Medical Center

Collaborators

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