Deep Phenotyping of Bone Disease in Type 2 Diabetes and Relations to Diabetic Neuropathy

Conditions

• Type 2 Diabetes
• Bone Disease
• Osteoporosis
• Diabetic Neuropathy Peripheral
• Autonomic Neuropathy, Diabetic

Interventions

• DIAGNOSTIC_TEST: Dual Energy X-ray Absorbtiometry scan
• DIAGNOSTIC_TEST: High-resolution peripheral quantitative computed tomography
• DIAGNOSTIC_TEST: Microindentation
• DIAGNOSTIC_TEST: Thermal perception thresholds
• DIAGNOSTIC_TEST: Nerve conduction studies
• DIAGNOSTIC_TEST: Composite Autonomic Symptom Score 31
• DIAGNOSTIC_TEST: Skin biopsies with quantification of intra-epidermal nerve fibre density
• DIAGNOSTIC_TEST: Perception Threshold Tracking
• DIAGNOSTIC_TEST: Assessment of cardiovascular autonomic neuropathy
• DIAGNOSTIC_TEST: Handgrip strength
• DIAGNOSTIC_TEST: Force plate platform
• DIAGNOSTIC_TEST: Biospecimen collection
• DIAGNOSTIC_TEST: Isometric leg extension strength
• DIAGNOSTIC_TEST: Michigan Neuropathy Screening Instrument

Sponsor

Aalborg University Hospital