Clinical and Diagnostic Significance of Endothelial Dysfunction and Myocardial Contractility in Patients With AML

Conditions

• Acute Myeloid Leukemia, Adult
• Cardiotoxicity
• Endothelial Dysfunction

Interventions

• DIAGNOSTIC_TEST: History taking
• DIAGNOSTIC_TEST: Anthropometry
• DIAGNOSTIC_TEST: Complete blood count
• DIAGNOSTIC_TEST: Biochemical blood test
• DIAGNOSTIC_TEST: Coagulogram
• DIAGNOSTIC_TEST: Immunoenzymatic analysis of the level of endothelin-1, asymmetric dimethylarginine
• DIAGNOSTIC_TEST: Stress echocardiography with the definition of global longitudinal deformation of the myocardium
• DIAGNOSTIC_TEST: Triplex scanning of neck vessels
• DIAGNOSTIC_TEST: Electrocardiography
• DIAGNOSTIC_TEST: Ultrasound of the abdominal cavity (with calculation of the area of the spleen) and lymph nodes
• DIAGNOSTIC_TEST: Cytogenetic examination of the bone marrow to determine genetic abnormalities.
• DIAGNOSTIC_TEST: Cytological examination of bone marrow cells with cytochemical examination
• DIAGNOSTIC_TEST: Immunophenotypic examination of the bone marrow by flow cytometry
• DIAGNOSTIC_TEST: Determination of the presence of a FLT3 mutation using the PCR Method
• DIAGNOSTIC_TEST: laser Doppler flowmetry

Sponsor

Samara State Medical University