A Study of Revumenib in Combination With Chemotherapy for Patients Diagnosed With Relapsed or Refractory Leukemia

Conditions

• Recurrent Acute Leukemia of Ambiguous Lineage
• Recurrent Acute Lymphoblastic Leukemia
• Recurrent Acute Myeloid Leukemia Due to Lineage Switch From Acute Leukemia of Ambiguous Lineage
• Recurrent Acute Myeloid Leukemia Due to Lineage Switch From B Acute Lymphoblastic Leukemia, KMT2A-Rearranged
• Recurrent Acute Myeloid Leukemia Due to Lineage Switch From Mixed Phenotype Acute Leukemia
• Recurrent Mixed Phenotype Acute Leukemia
• Refractory Acute Leukemia of Ambiguous Lineage
• Refractory Acute Lymphoblastic Leukemia
• Refractory Acute Myeloid Leukemia Due to Lineage Switch From Acute Leukemia of Ambiguous Lineage
• Refractory Acute Myeloid Leukemia Due to Lineage Switch From B Acute Lymphoblastic Leukemia, KMT2A-Rearranged
• Refractory Acute Myeloid Leukemia Due to Lineage Switch From Mixed Phenotype Acute Leukemia
• Refractory Mixed Phenotype Acute Leukemia

Interventions

• PROCEDURE: Biospecimen Collection
• PROCEDURE: Bone Marrow Aspiration
• DRUG: Calaspargase Pegol
• DRUG: Cytarabine
• PROCEDURE: Echocardiography Test
• PROCEDURE: Electrocardiogram
• DRUG: Fludarabine Phosphate
• DRUG: Hydrocortisone Sodium Succinate
• PROCEDURE: Lumbar Puncture
• DRUG: Methotrexate
• PROCEDURE: Multigated Acquisition Scan
• DRUG: Prednisolone
• DRUG: Prednisone
• DRUG: Revumenib
• DRUG: Vincristine Sulfate

Sponsor

Children's Oncology Group