Adaptive Platform Trial for Personnalisation of Sepsis Treatment in Children and Adults: a Multi-national, Treatable Traits-guided, Adaptive, Exploratory, Bayesian Basket Trial

NCT06381661 · clinicaltrials.gov ↗

PHASE2

Phase

NOT_YET_RECRUITING

Status

2000

Enrollment

OTHER

Sponsor class

Conditions

Sepsis

Interventions

DRUG: Tocilizumab
DRUG: Baricitinib
DRUG: Anakinra
DRUG: Hydrocortisone
DRUG: Hydrocortisone and fludrocortisone
DRUG: Heparin
DRUG: Low molecular weight heparin
DRUG: Recombinant humanThrombomodulin( rhTM)
DRUG: Sivelestat
OTHER: Usual care
OTHER: blood purification with MTx.100 Plasma Adsorption Column
DRUG: G-CSF filgrastim
DRUG: Interferon gamma-1b
DRUG: Fludrocortisone
DRUG: Prophylactic unfractionated heparin (UFH)
DRUG: Octaplas LG
DRUG: Plasminogen

Sponsor

Assistance Publique - Hôpitaux de Paris