The Proposed Study Aims to Investigate the Impact of Adjunctive Vitamin D Gel Application on Gingival Crevicular Fluid Levels of Alkaline Phosphatase and Interleukin-8 in Periodontitis Patients Undergoing Phase 1 Periodontal Therapy. By Elucidating the Molecular Mechanisms Underlying the Therapeutic

Conditions

• Periodontal Pocket

Interventions

• DIETARY_SUPPLEMENT: vitamin D loaded Poly lactic-co-glycolic acid nanoparticles gel
• DIETARY_SUPPLEMENT: vitamin D3 gel (regular non-nanoparticle form)
• OTHER: Poly lactic-co-glycolic acid nanoparticles placebo gel
• PROCEDURE: only mechanical debridement

Sponsor

Mansoura University