Chemotherapy (Decitabine in Combination With FLAG-Ida) and Total-Body Irradiation Followed by Donor Stem Cell Transplant for the Treatment of Adults With Myeloid Malignancies at High Risk of Relapse

NCT06928662 · clinicaltrials.gov ↗

PHASE1,PHASE2

Phase

RECRUITING

Status

36

Enrollment

OTHER

Sponsor class

Conditions

Acute Myeloid Leukemia
Acute Undifferentiated Leukemia
Mixed Phenotype Acute Leukemia
Recurrent Acute Myeloid Leukemia
Recurrent Acute Undifferentiated Leukemia
Recurrent Chronic Myelomonocytic Leukemia
Recurrent Mixed Phenotype Acute Leukemia
Recurrent Myelodysplastic Syndrome
Refractory Acute Myeloid Leukemia
Refractory Acute Undifferentiated Leukemia
Refractory Chronic Myelomonocytic Leukemia
Refractory Mixed Phenotype Acute Leukemia
Refractory Myelodysplastic Syndrome
Secondary Acute Myeloid Leukemia

Interventions

DRUG: Decitabine
PROCEDURE: Bone Marrow Aspiration
PROCEDURE: Bone Marrow Biopsy
PROCEDURE: Chest Radiography
DRUG: Cytarabine
PROCEDURE: Echocardiography Test
BIOLOGICAL: Filgrastim
DRUG: Fludarabine
PROCEDURE: Hematopoietic Cell Transplantation
DRUG: Idarubicin
PROCEDURE: Multigated Acquisition Scan
PROCEDURE: Pheresis
RADIATION: Total-Body Irradiation
PROCEDURE: Biospecimen Collection

Sponsor

Fred Hutchinson Cancer Center