Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post Consolidation

NCT06942039 · clinicaltrials.gov ↗

EARLY_PHASE1

Phase

RECRUITING

Status

15

Enrollment

OTHER

Sponsor class

Conditions

CNS Embryonal Tumor
CNS, Medulloblastoma
Atypical Teratoid Rhabdoid Tumor
Medulloblastoma, Childhood
Medulloblastoma, Group 3
Medulloblastoma, Group 4
Pineoblastoma
Neuroblastoma
Embryonal Tumor With Multilayered Rosettes
Embryonal Tumor With Abundant Neuropil and True Rosettes
Ependymoblastoma
Medulloepithelioma
CNS Embryonal Tumor With Rhabdoid Features
CNS Embryonal Tumor, Nos

Interventions

DRUG: Cytarabine IT
DRUG: hydrocortisone
DRUG: Cisplatin
DRUG: Vincristine
DRUG: Etoposide
DRUG: Cyclophosphamide
DRUG: Mesna
DRUG: Filgrastim
DRUG: carboplatin
DRUG: Thiotepa
DRUG: Topotecan IT
DRUG: Tamoxifen
DRUG: ISOtretinoin
DRUG: Celecoxib
DRUG: etoposide phosphate
DRUG: Temozolomide

Sponsor

C17 Council