Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic Cancer

Conditions

• Locally Advanced Unresectable Pancreatic Ductal Adenocarcinoma
• Stage II Pancreatic Cancer AJCC v8
• Stage III Pancreatic Cancer AJCC v8
• Stage IV Pancreatic Cancer AJCC v8

Interventions

• PROCEDURE: Biopsy Procedure
• PROCEDURE: Biospecimen Collection
• DRUG: Capecitabine
• PROCEDURE: Computed Tomography
• RADIATION: Dose-escalated Radiation Therapy
• DRUG: Fluorouracil
• DRUG: Gemcitabine
• DRUG: Irinotecan Hydrochloride
• DRUG: Irinotecan Sucrosofate
• DRUG: Leucovorin Calcium
• PROCEDURE: Magnetic Resonance Imaging
• DRUG: Nab-paclitaxel
• OTHER: Observation Activity
• DRUG: Oxaliplatin
• PROCEDURE: Positron Emission Tomography
• OTHER: Questionnaire Administration
• RADIATION: Radiation Therapy

Sponsor

NRG Oncology