Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer

NCT07061977 · clinicaltrials.gov ↗

PHASE3

Phase

RECRUITING

Status

336

Enrollment

NIH

Sponsor class

Conditions

Locally Advanced Cervical Adenocarcinoma
Locally Advanced Cervical Adenosquamous Carcinoma
Locally Advanced Cervical Squamous Cell Carcinoma
Stage IIIA Cervical Cancer FIGO 2018
Stage IIIB Cervical Cancer FIGO 2018
Stage IIIC1 Cervical Cancer FIGO 2018
Stage IIIC2 Cervical Cancer FIGO 2018
Stage IVA Cervical Cancer FIGO 2018

Interventions

PROCEDURE: Biospecimen Collection
RADIATION: Brachytherapy
DRUG: Carboplatin
PROCEDURE: Chest Radiography
DRUG: Cisplatin
PROCEDURE: Computed Tomography
RADIATION: External Beam Radiation Therapy
RADIATION: Intensity-Modulated Radiation Therapy
PROCEDURE: Magnetic Resonance Imaging
DRUG: Paclitaxel
BIOLOGICAL: Pembrolizumab
PROCEDURE: Positron Emission Tomography

Sponsor

National Cancer Institute (NCI)