Testing the Addition of Daratumumab to Chemotherapy for Treating Patients With Newly-Diagnosed T-Cell Lymphoblastic Leukemia (T-ALL) and T-Cell Lymphoblastic Lymphoma (T-LL)

NCT07072585 · clinicaltrials.gov ↗

PHASE2,PHASE3

Phase

NOT_YET_RECRUITING

Status

1708

Enrollment

NETWORK

Sponsor class

Conditions

Stage II T Lymphoblastic Leukemia/Lymphoma
Stage III T Lymphoblastic Leukemia/Lymphoma
Stage IV T Lymphoblastic Leukemia/Lymphoma
T Acute Lymphoblastic Leukemia
T Lymphoblastic Lymphoma

Interventions

PROCEDURE: Biopsy Procedure
PROCEDURE: Biospecimen Collection
PROCEDURE: Bone Marrow Aspiration
PROCEDURE: Bone Marrow Biopsy
PROCEDURE: Bone Scan
DRUG: Bortezomib
DRUG: Calaspargase Pegol
PROCEDURE: Computed Tomography
DRUG: Cyclophosphamide
DRUG: Cytarabine
BIOLOGICAL: Daratumumab
DRUG: Daunorubicin Hydrochloride
DRUG: Dexamethasone
DRUG: Doxorubicin Hydrochloride
PROCEDURE: Echocardiography Test
PROCEDURE: Lumbar Puncture
PROCEDURE: Magnetic Resonance Imaging
DRUG: Mercaptopurine Oral Suspension
DRUG: Methotrexate
DRUG: Methylprednisolone

Sponsor

Children's Oncology Group