Facilitation of Extinction Retention and Reconsolidation Blockade by IV Allopregnanolone in PTSD.
Conditions
- Post Traumatic Stress Disorder
Interventions
- BEHAVIORAL: Experiment 1: Three-day aversive conditioning, extinction, and extinction retention testing paradigm
- DRUG: Allopregnanolone (Allo) with 6% USP Dexolve (sulfobutyl ether-beta-cyclodextrin sodium salt) in 0.9% saline for IV infusion will be provided by the University of California, Davis, GMP manufacturer.
- BEHAVIORAL: Experiment 1. Three-day aversive conditioning, extinction, and extinction retention testing paradigm
- OTHER: Matching IV Placebo
- BEHAVIORAL: Experiment 2. Three-day aversive conditioning, reconsolidation blockade, and testing paradigm
- DRUG: Allopregnanolone (Allo) with 6% USP Dexolve (sulfobutyl ether-beta-cyclodextrin sodium salt) in 0.9% saline for IV infusion will be provided by the University of California, Davis, GMP manufacturer.
- BEHAVIORAL: Experiment 2. Three-day aversive conditioning, reconsolidation blockade, and testing paradigm
- OTHER: Matching IV Placebo
Sponsor
Massachusetts General Hospital
Collaborators