Mechanisms of Pain Hypersensitivity in a Human Skin Inflammation Model

NCT07092215 · clinicaltrials.gov ↗

EARLY_PHASE1

Phase

COMPLETED

Status

42

Enrollment

OTHER

Sponsor class

Conditions

Pain

Interventions

DRUG: Synthetic interstitial fluid (SIF) / SIF neutral pH
DRUG: Synthetic interstitial fluid (SIF) / SIF acidic pH
DRUG: Synthetic interstitial fluid (SIF) / SIF acidic pH + BCTC 1 µM
DRUG: LPS 5 ng / SIF neutral pH
DRUG: LPS 5 ng / SIF acidic pH
DRUG: LPS 5 ng / SIF acidic pH + BCTC 1 µM
DRUG: LPS 5 ng + Azeliragon 100 µM / SIF neutral pH
DRUG: LPS 5 ng + Azeliragon 100 µM / SIF acidic pH
DRUG: LPS 5 ng + Resatorvid 10 µM / SIF neutral pH
DRUG: LPS 5 ng + Resatorvid 10 µM / SIF acidic pH

Sponsor

Stefan Heber