Ruxolitinib Before, During and After Hematopoietic Cell Transplant in Older Patients With Myelofibrosis and Myelodysplastic Syndrome/Myeloproliferative Neoplasm Overlap Syndromes

NCT07228624 · clinicaltrials.gov ↗

PHASE2

Phase

RECRUITING

Status

50

Enrollment

OTHER

Sponsor class

Conditions

Myelodysplastic/Myeloproliferative Neoplasm
Primary Myelofibrosis
Secondary Myelofibrosis

Interventions

DRUG: Ruxolitinib
PROCEDURE: Allogeneic Hematopoietic Stem Cell Transplantation
DRUG: Busulfan
PROCEDURE: Computed Tomography
DRUG: Cyclophosphamide
PROCEDURE: Echocardiography Test
DRUG: Fludarabine
DRUG: JAK Inhibitor
DRUG: Melphalan
DRUG: Methotrexate
DRUG: Tacrolimus
PROCEDURE: Biospecimen Collection
PROCEDURE: Bone Marrow Aspiration
PROCEDURE: Bone Marrow Biopsy

Sponsor

Fred Hutchinson Cancer Center

Collaborators

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