B7-H3.CD28Z.CART in CNS Neoplasms

NCT07390539 · clinicaltrials.gov ↗

PHASE1

Phase

NOT_YET_RECRUITING

Status

70

Enrollment

OTHER

Sponsor class

Conditions

Central Nervous System Neoplasms
Brain Tumor
Brain Tumor, Recurrent
Brain Tumor, Pediatric
Brain Tumor Adult
Medulloblastoma
Medulloblastoma, Childhood
Medulloblastoma, Adult
Medulloblastoma Recurrent
Ependymoma
Atypical Teratoid/Rhabdoid Tumor
Embryonal Tumor With Multilayered Rosettes
Pineoblastoma
Leptomeningeal Disease

Interventions

BIOLOGICAL: B7-H3.CD28Z.CART
DRUG: Fludarabine
DRUG: Cyclophosphamide

Sponsor

Robbie Majzner

Collaborators

National Institutes of Health (NIH)