Locoregional Administration of Genetically Engineered Cells (EGFR/IL13Rα2 Pool-CAR T Cells) for the Treatment of Recurrent or Progressive High-Grade Gliomas

NCT07544992 · clinicaltrials.gov ↗

PHASE1

Phase

RECRUITING

Status

24

Enrollment

OTHER

Sponsor class

Conditions

Recurrent Astrocytoma, IDH-Mutant, Grade 4
Recurrent Glioblastoma, IDH-Wildtype

Interventions

BIOLOGICAL: Autologous Anti-EGFR/Anti-IL13Ralpha2 CAR T-cells
PROCEDURE: Biopsy Procedure
PROCEDURE: Biospecimen Collection
PROCEDURE: Echocardiography Test
PROCEDURE: FDG-Positron Emission Tomography
PROCEDURE: Intracranial Catheter Placement
PROCEDURE: Leukapheresis
PROCEDURE: Magnetic Resonance Imaging
PROCEDURE: Resection

Sponsor

City of Hope Medical Center

Collaborators

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