The substances plants produce for protection against pests, and the genetic material necessary to produce these substances, are pesticides under the Federal Insecticide, Fungicide and Rodenticide Act (FIFRA), if humans intend to use these substances for "preventing, repelling or mitigating any pest." In this rule, EPA finalizes certain of the proposed rules published in 1994, 1996, and 1997. Specifically, EPA changes the name of this type of pesticide from "plant-pesticide" to "plant-incorporated protectant"; clarifies the relationship between plants and plant-incorporated protectants under FIFRA; exempts from FIFRA requirements plant-incorporated protectants derived through conventional breeding from sexually compatible plants; and establishes a new part in the Code of Federal Regulations (CFR) specifically for plant-incorporated protectants. Procedures are also set forth for Confidential Business Information (CBI); any claim of confidentiality must be substantiated when the claim is made. This rule will benefit the public by ensuring that public health and the environment are adequately protected while reducing burden on the regulated community, thereby potentially reducing costs for consumers.