This final rule restricts or prohibits substitutes for ozone depleting substances (ODSs) under the U.S. Environmental Protection Agency (EPA) Significant New Alternatives Policy (SNAP) program. SNAP implements section 612 of the amended Clean Air Act of 1990 which requires EPA to evaluate and regulate substitutes for the ODSs to reduce overall risk to human health and the environment. Through these evaluations, SNAP generates lists of acceptable and unacceptable substitutes for each of the major industrial use sectors. The intended effect of the SNAP program is to expedite movement away from ozone depleting compounds while avoiding a shift into high-risk substitutes posing other environmental problems. In this final rule, EPA is issuing decisions on the acceptability of certain substitutes proposed by the Agency on September 26, 1994 (59 FR 49108). To arrive at determinations on the acceptability of substitutes, the Agency completed a cross-media evaluation of risks to human health and the environment by sector end-use. Public comments received regarding this rulemaking have been fully summarized and responded to in the relevant sector sections of this rule. Therefore, no separate comment response document has been developed to accompany this rulemaking. Copies of the eleven public comments received on the NPRM are available in the public docket supporting this final rule.