EPA is issuing a significant new use rule (SNUR) under section 5(a)(2) of the Toxic Substances Control Act (TSCA) for the chemical substance described as polyalkylene polyamine which is the subject of premanufacture notice (PMN) P-89-963. This rule would require certain persons who intend to manufacture, or import this substance for a significant new use to notify EPA at least 90 days before commencing any manufacturing or importing activities for a use designated by this SNUR as a significant new use. The required notice would provide EPA with the opportunity to evaluate the intended use and, if necessary, to prohibit or limit that activity before it can occur.