Project Summary Exposure to discrimination-related stressors (e.g., racial/ethnic discrimination, unfair treatment) continues to pose a public health challenge to minority populations as a social determinant of health. Although discrimination-related stressors have been consistently associated with poor mental health outcomes, there is a critical need to identify mechanisms and malleable risk/protective factors to integrate in the design of community and clinical interventions. The overall objective of this R01 application is to investigate mediators and moderators at multiple ecological (individual, family/peer and school/neighborhood levels) and time-scale (micro- and macro-time) levels in the link between discrimination-related stressors and mental health among 340 Mexican-origin youth. Guided by a socioecological, life course perspective, the proposed project has three specific aims: (1) determine within-person discrimination-related stressors that impact Mexican-American origin youth’s mental health outcomes as well as the mechanisms of action at both micro- and macro-time levels; (2) identify protective factors that could help youth to successfully cope with discrimination-related stressors and the conditions under which those protective factors work; and (3) elucidate the youth, parent, and neighborhood risk factors that moderate the link between discrimination-related stressors and mental health in youth. The project’s long-term goal is to improve the mental health of Mexican-origin youth by reducing the deleterious effects of racism, “othering,” and negative neighborhood interactions. The central hypothesis is that this link will be mediated by cognitive and/or affective mechanisms (i.e. anger, hypervigilance, emotion regulation, low social position as threats to self-worth) and moderated by coping resources (parental adaptation and racial socialization) and family, peer, and neighborhood supports, thus representing multiple ecological levels. Community-based collaboration will help ensure recruitment of the targeted sample of Mexican-origin adolescents, mothers, and fathers; the inclusion of fathers will be a valuable contribution to the literature, given the dearth of studies on Latinx fathers/stepfathers. Through the innovative integration of both yearly longitudinal (macro-time) and daily diary (micro-time) research design features, important questions about how mediating and moderating processes unfold over time will be addressed. The proposed analyses also reflect the multi-layered sociocultural niches occupied by Latinx adolescents by employing individual-level methods as well as dyadic (adolescent-mother; adolescent-father) and triadic (adolescent-mother-father) analyses to test key study hypotheses. Considering the current growth of Latinx immigrants, it is imperative to test a socioecological model of risk and resilience for Mexican-origin adolescents that is responsive to both their immediate context and the larger global fo...